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  1. Novel, less toxic, cost-effective and safe therapeutic strategies are needed to improve treatment of chronic lymphocytic leukemia (CLL). Ascorbic acid (AA, vitamin C) has shown a potential anti-cancer therapeu...

    Authors: Walaa Darwiche, Cathy Gomila, Hakim Ouled-Haddou, Marie Naudot, Cécile Doualle, Pierre Morel, Florence Nguyen-Khac, Loïc Garçon, Jean-Pierre Marolleau and Hussein Ghamlouch

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:228

    Content type: Research

    Published on:

  2. Increased tissue stiffness is a common feature of malignant solid tumors, often associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix anchorage glycoprotein related to a...

    Authors: Amparo López-Carrasco, Susana Martín-Vañó, Rebeca Burgos-Panadero, Ezequiel Monferrer, Ana P. Berbegall, Beatriz Fernández-Blanco, Samuel Navarro and Rosa Noguera

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:226

    Content type: Research

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  3. Colon cancer represents one of the leading causes of gastrointestinal tumors in industrialized countries, and its incidence appears to be increasing at an alarming rate. Accumulating evidence has unveiled the ...

    Authors: Longgang Wang, Jinxiang Guo, Jin Zhou, Dongyang Wang, Xiuwen Kang and Lei Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:225

    Content type: Research

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  4. Hypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normo...

    Authors: Tiansheng Li, Chao Mao, Xiang Wang, Ying Shi and Yongguang Tao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:224

    Content type: Review

    Published on:

  5. Accumulating evidence supports that lysine-specific demethylase 5 (KDM5) family members act as oncogenic drivers. This study was performed to elucidate the potential effects of KDM5A on prostate cancer (PCa) p...

    Authors: Chen Du, Caihong Lv, Yue Feng and Siwen Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:223

    Content type: Research

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  6. Radioresistance is the major obstacle in radiation therapy (RT) for hepatocellular carcinoma (HCC). Dysregulation of DNA damage response (DDR), which includes DNA repair and cell cycle checkpoints activation, ...

    Authors: Jingyuan Sun, Zhenru Zhu, Wenwen Li, Mengying Shen, Chuanhui Cao, Qingcan Sun, Zeqin Guo, Li Liu and Dehua Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:222

    Content type: Research

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  7. Peritoneal metastasis (PM) is an important pathological process in the progression of gastric cancer (GC). The metastatic potential of tumor and stromal cells is governed by hypoxia, which is a key molecular f...

    Authors: Xiaoxun Wang, Xiaofang Che, Yang Yu, Yu Cheng, Ming Bai, Zichang Yang, Qiqiang Guo, Xiaochen Xie, Danni Li, Min Guo, Kezuo Hou, Wendong Guo, Xiujuan Qu and Liu Cao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:221

    Content type: Research

    Published on:

  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lihua Guo, Hua Bai, Dongling Zou, Tao Hong, Jie Liu, Jiaqiang Huang, Pengfei He, Qi Zhou and Jinsheng He

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:220

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2014 33:99

  9. Small cell lung cancer (SCLC) is a deadly neuroendocrine tumor with limited therapeutic options. Recent data suggest that histone deacetylases (HDACs) and the phosphatidylinositol 3-kinase (PI3K) pathway play ...

    Authors: Liying Ma, Xing Bian and Wenchu Lin

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:219

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:7

  10. Glioblastoma is a common disease of the central nervous system (CNS), with high morbidity and mortality. In the infiltrate in the tumor microenvironment, tumor-associated macrophages (TAMs) are abundant, which...

    Authors: Shuai Han, Wei Zhen, Tongqi Guo, Jianjun Zou and Fuyong Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:218

    Content type: Research

    Published on:

  11. Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outco...

    Authors: Kara M. Ruicci, Jalna Meens, Paul Plantinga, William Stecho, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Christopher J. Howlett, Paul C. Boutros, Laurie Ailles and Anthony C. Nichols

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:217

    Content type: Research

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  12. Long noncoding RNA (lncRNA) Linc00337 has been implicated in lung, gastric, colorectal and esophageal squamous cell carcinoma progression via various mechanisms; however, its clinicopathological significance a...

    Authors: Huakai Wang, Shiyong Yu, Huan Peng, Yijun Shu, Wenjie Zhang, Qi Zhu, Yingxia Wu, Yijun Xu, Jiqi Yan and Honggang Xiang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:216

    Content type: Research

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  13. Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse...

    Authors: Xiang Gu, Jie Yu, Peiwei Chai, Shengfang Ge and Xianqun Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:215

    Content type: Review

    Published on:

  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jian Zhang, Xin Wen, Xian-Yue Ren, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Na Liu and Jun Ma

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:214

    Content type: Correction

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:109

  15. Despite the introduction of several novel therapeutic approaches that improved survival, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable disease. Herein we report the synergistic a...

    Authors: Federica Iannelli, Maria Serena Roca, Rita Lombardi, Chiara Ciardiello, Laura Grumetti, Simona De Rienzo, Tania Moccia, Carlo Vitagliano, Angela Sorice, Susan Costantini, Maria Rita Milone, Biagio Pucci, Alessandra Leone, Elena Di Gennaro, Rita Mancini, Gennaro Ciliberto…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:213

    Content type: Research

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  16. The X-linked gene WTX (also called AMER1) has been reported to function as a tumour suppressor gene in Wilms’ tumour. In our previous study, WTX expression was shown to be significantly reduced in gastric canc...

    Authors: Jian Li, Danli Ye, Peng Shen, Xiaorong Liu, Peirong Zhou, Guifang Zhu, Yangwei Xu, Yun Fu, Xuanqi Li, Jingbo Sun, Jia Xu and Qingling Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:212

    Content type: Research

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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:46

  17. Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In the present study the anti-melanoma activity of Nicotinamide (NAM), the...

    Authors: Francesca Scatozza, Federica Moschella, Daniela D’Arcangelo, Stefania Rossi, Claudio Tabolacci, Claudia Giampietri, Enrico Proietti, Francesco Facchiano and Antonio Facchiano

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:211

    Content type: Research

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  18. Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy d...

    Authors: Claudio Pulito, Antonio Cristaudo, Caterina La Porta, Stefano Zapperi, Giovanni Blandino, Aldo Morrone and Sabrina Strano

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:210

    Content type: Review

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  19. Our previous study showed that calreticulin (CRT) promoted EGF-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) via Integrin/EGFR-ERK/MAPK signaling. We next investigated the novel sig...

    Authors: Weiwei Sheng, Guosen Wang, Jingtong Tang, Xiaoyang Shi, Rongxian Cao, Jian Sun, Yi Heng Lin, Chao Jia, Chuanping Chen, Jianping Zhou and Ming Dong

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:209

    Content type: Research

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  20. High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal prognosis with a median survival of le...

    Authors: Faiqa Mudassar, Han Shen, Geraldine O’Neill and Eric Hau

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:208

    Content type: Review

    Published on:

  21. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) acting as crucial regulators in tumorigenesis. However, its biological functions of lncRNAs in colorectal cancer (CRC) have not been systemat...

    Authors: Xiaojian Zhu, Fanqin Bu, Ting Tan, Qilin Luo, Jinfeng Zhu, Kang Lin, Jun Huang, Chen Luo and Zhengming Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:207

    Content type: Research

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  22. Although the aberrant expression and function of most Ca2+-permeable channels are known to promote gastrointestinal tumors, the association between transient receptor potential vanilloid receptor 1 (TRPV1) channe...

    Authors: Nannan Gao, Feng Yang, Siyuan Chen, Hanxing Wan, Xiaoyan Zhao and Hui Dong

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:206

    Content type: Research

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  23. The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cancer cells is highly dynamic and ...

    Authors: Julia Arnold, Juliana Schattschneider, Christine Blechner, Christoph Krisp, Hartmut Schlüter, Michaela Schweizer, Marcus Nalaskowski, Leticia Oliveira-Ferrer and Sabine Windhorst

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:205

    Content type: Research

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  24. Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor ce...

    Authors: Xianjie Jiang, Jie Wang, Xiangying Deng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Ke Cao, Hao Deng, Yi He, Qianjin Liao, Bo Xiang, Ming Zhou, Can Guo, Zhaoyang Zeng, Guiyuan Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:204

    Content type: Review

    Published on:

  25. N6-Methyladenosine (m6A) modification has been implicated in multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A reader, whereas its role in colon cancer remains unclear.

    Authors: Zhou Yang, Tingfeng Wang, Dejun Wu, Zhijun Min, Jingyun Tan and Bo Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:203

    Content type: Research

    Published on:

  26. Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked to CRC recentl...

    Authors: Pin Guo, Zibin Tian, Xinjuan Kong, Lin Yang, Xinzhi Shan, Bingzi Dong, Xueli Ding, Xue Jing, Chen Jiang, Na Jiang and Yanan Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:202

    Content type: Research

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  27. Although cisplatin-based chemotherapy represents the standard regimen for osteosarcoma (OS), OS patients often exhibit treatment failure and poor prognosis due to chemoresistance to cisplatin. Emerging researc...

    Authors: Dong Yang, Tianyang Xu, Lin Fan, Kaiyuan Liu and Guodong Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:201

    Content type: Research

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    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:17

  28. SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in ...

    Authors: Andrea Sacconi, Sara Donzelli, Claudio Pulito, Stefano Ferrero, Francesca Spinella, Aldo Morrone, Marta Rigoni, Fulvia Pimpinelli, Fabrizio Ensoli, Giuseppe Sanguineti, Raul Pellini, Nishant Agrawal, Evgeny Izumchenko, Gennaro Ciliberto, Aldo Giannì, Paola Muti…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:200

    Content type: Research

    Published on:

  29. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma and Bo Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:199

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:93

  30. Advanced colorectal adenocarcinoma (CRAC), featured by distinctive histopathological appearance, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a group of heterogeneous cancers...

    Authors: Hang-Ping Yao, Xiang-Min Tong, Rachel Hudson and Ming-Hai Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:198

    Content type: Review

    Published on:

  31. Autophagy is an intracellular process through which intracellular components are recycled in response to nutrient or growth factor deficiency to maintain homeostasis. We identified the peptide autophagy-relate...

    Authors: Yang Yang, Qi Wang, Dongjian Song, Ruirui Zen, Lei Zhang, Yingjun Wang, Heying Yang, Da Zhang, Jia Jia, Jiao Zhang and Jiaxiang Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:197

    Content type: Research

    Published on:

  32. Glioblastoma is the most common primary malignant intracranial tumor with poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) function as important regulators...

    Authors: Xiaoming Zhang, Wanxiang Niu, Maolin Mu, Shanshan Hu and Chaoshi Niu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:196

    Content type: Research

    Published on:

  33. Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have...

    Authors: Diana Corallo, Fabio Pastorino, Marcella Pantile, Elena Mariotto, Federico Caicci, Giampietro Viola, Mirco Ponzoni, Gian Paolo Tonini and Sanja Aveic

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:195

    Content type: Research

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  34. Nuclear casein kinase and cyclin-dependent kinase substrate (NUCKS), a novel gene first reported in 2001, is a member of the high mobility group (HMG) family. Although very little is known regarding the biolog...

    Authors: Erhu Zhao, Liying Feng, Longchang Bai and Hongjuan Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:194

    Content type: Research

    Published on:

  35. Angiogenesis, a basic requirement for tumor cell survival, is considered to be a malignant characteristic of small cell lung cancer (SCLC) and is closely related to the poor outcomes of SCLC patients. miR-141 ...

    Authors: Shuangshuang Mao, Zhiliang Lu, Sufei Zheng, Hao Zhang, Guochao Zhang, Feng Wang, Jianbing Huang, Yuanyuan Lei, Xinfeng Wang, Chengming Liu, Nan Sun and Jie He

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:193

    Content type: Research

    Published on:

  36. The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the mo...

    Authors: Yuhao Zhang, Xiuchao Geng, Qiang Li, Jianglong Xu, Yanli Tan, Menglin Xiao, Jia Song, Fulin Liu, Chuan Fang and Hong Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:192

    Content type: Review

    Published on:

  37. Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be in...

    Authors: Sifeng Tao, Qiang Chen, Chen Lin and Haiying Dong

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:191

    Content type: Research

    Published on:

  38. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients’ poor prognosis. However, the functions of ...

    Authors: Xiang Zhang, Dawei Wang, Boke Liu, Xingwei Jin, Xianjin Wang, Junwei Pan, Weichao Tu and Yuan Shao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:190

    Content type: Research

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  39. Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)...

    Authors: Alberto Ocaña and Atanasio Pandiella

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:189

    Content type: Review

    Published on:

  40. Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t...

    Authors: Yilan Yang, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Xiaomao Guo and Xiaoli Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:188

    Content type: Review

    Published on:

  41. Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modif...

    Authors: Shanshan Zhao, Xue Zhang, Shuo Chen and Song Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:187

    Content type: Review

    Published on:

  42. Bladder cancer (BC) is a common genitourinary malignancy worldwide. Circular RNAs (circRNAs) participate in cancer development, including BC; thus, the roles of circRNAs in this process have attracted signific...

    Authors: Mingming Jin, Shengjie Lu, Yue Wu, Chen Yang, Chunzi Shi, Yanqiu Wang and Gang Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:186

    Content type: Research

    Published on:

  43. Molecular oxygen (O2) is a universal electron acceptor that is eventually synthesized into ATP in the mitochondrial respiratory chain of all metazoans. Therefore, hypoxia biology has become an organizational prin...

    Authors: Mingyao Huang, Liang Yang, Xueqiang Peng, Shibo Wei, Qing Fan, Shuo Yang, Xinyu Li, Bowen Li, Hongyuan Jin, Bo Wu, Jingang Liu and Hangyu Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:185

    Content type: Review

    Published on:

  44. The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant gene...

    Authors: Andrew Brennan, James T. Leech, Neil M. Kad and Jody M. Mason

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:184

    Content type: Review

    Published on:

  45. NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and metastasis, but its role in cervical cancer radioresistance remains unknown.

    Authors: Tie Xu, Yulan Zeng, Linli Shi, Qin Yang, Yeshan Chen, Gang Wu, Guiling Li and Shuangbing Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:183

    Content type: Research

    Published on:

  46. Glioma is the most common and lethal primary brain tumor in adults, and angiogenesis is one of the key factors contributing to its proliferation, aggressiveness, and malignant transformation. However, the disc...

    Authors: Yang Jiang, Jinpeng Zhou, Junshuang Zhao, Haiying Zhang, Long Li, Hao Li, Lian Chen, Jiangfeng Hu, Wei Zheng and Zhitao Jing

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:182

    Content type: Research

    Published on:

  47. Nicotine, an active ingredient in tobacco, can promote epithelial-to-mesenchymal transition (EMT) processes that enhance the aggressiveness of a number of human cancers. In the present study, we investigated w...

    Authors: Qiwen Ben, Wei An, Yunwei Sun, Aihua Qian, Jun Liu, Duowu Zou and Yaozong Yuan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:181

    Content type: Research

    Published on:

  48. Triple-negative breast cancer (TNBC) is a uniquely aggressive cancer with high rates of relapse due to resistance to chemotherapy. TNBC expresses higher levels of programmed cell death-ligand 1 (PD-L1) compare...

    Authors: Simona Camorani, Margherita Passariello, Lisa Agnello, Silvia Esposito, Francesca Collina, Monica Cantile, Maurizio Di Bonito, Ilya V. Ulasov, Monica Fedele, Antonella Zannetti, Claudia De Lorenzo and Laura Cerchia

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:180

    Content type: Research

    Published on:

  49. Accumulating evidence demonstrates the essential role of long non-coding RNA (lncRNA) in various types of cancers, including pancreatic cancer. However, the functions and regulation mechanism of lncRNA PMSB8-A...

    Authors: Hao Zhang, Changhao Zhu, Zhiwei He, Shiyu Chen, Lin Li and Chengyi Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:179

    Content type: Research

    Published on:

  50. Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improv...

    Authors: Juncheng Cui, Dylan Dean, Francis J. Hornicek, Zhiwei Chen and Zhenfeng Duan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:178

    Content type: Review

    Published on:

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