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  1. Induction therapy for acute myeloid leukemia (AML) is an anthracycline-based chemotherapy regimen. However, many patients experience a relapse or exhibit refractory disease (R/R). There is an urgent need for m...

    Authors: Hao Wang, Yu-chen Liu, Cheng-ying Zhu, Fei Yan, Meng-zhen Wang, Xiao-su Chen, Xiao-kai Wang, Bao-xu Pang, Yong-hui Li, Dai-hong Liu, Chun-ji Gao, Shu-jun Liu and Li-ping Dou

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:278

    Content type: Research

    Published on:

  2. Platinum-based anticancer drugs have been at the frontline of cancer therapy for the last 40 years, and are used in more than half of all treatments for different cancer types. However, they are not universall...

    Authors: Alice Domenichini, Ilaria Casari, Peter V. Simpson, Nima Maheshkumar Desai, Lingfeng Chen, Christopher Dustin, Jeanne S. Edmands, Albert van der Vliet, Moosa Mohammadi, Massimiliano Massi and Marco Falasca

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:276

    Content type: Research

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  3. Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during development, differentiation and maintenance of tissue hom...

    Authors: Anna Di Matteo, Elisa Belloni, Davide Pradella, Ambra Cappelletto, Nina Volf, Serena Zacchigna and Claudia Ghigna

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:275

    Content type: Review

    Published on:

  4. The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved i...

    Authors: Hong Wu, Tao Wang, Yiqiang Liu, Xin Li, Senlin Xu, Changtao Wu, Hongbo Zou, Mianfu Cao, Guoxiang Jin, Jinyi Lang, Bin Wang, Baohua Liu, Xiaolin Luo and Chuan Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:274

    Content type: Research

    Published on:

  5. MUC18 is a glycoprotein highly expressed on the surface of melanoma and other cancers which promotes tumor progression and metastasis. However, its mechanism of action and suitability as a therapeutic target a...

    Authors: Runhua Feng, Yuling Wang, Vijaya Ramachandran, Qinhong Ma, Matthew M. May, Ming Li, Joe X. Zhou, Xiang Xu, Kejing Xu, Shenying Fang, Weiya Xia, Dawen Sui, Huey Liu, Xiaolian Gao, Victor Prieto, Stephen C. Blacklow…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:273

    Content type: Research

    Published on:

  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Anquan Shang, Weiwei Wang, Chenzheng Gu, Chen Chen, Bingjie Zeng, Yibao Yang, Ping Ji, Junjun Sun, Junlu Wu, Wenying Lu, Zujun Sun and Dong Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:272

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:411

  7. An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in diverse cellular processes, including proliferation, apoptosis, migration, invasion, chromatin remodeling, ...

    Authors: Le Zhang, Cuixia Li and Xiulan Su

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:271

    Content type: Review

    Published on:

  8. Emerging evidence suggests that epithelial mesenchymal transition (EMT) and epigenetic mechanisms promote metastasis. Histone deacetylases (HDACs) and noncoding RNAs (ncRNAs) are important epigenetic regulators. ...

    Authors: Xue-ting Hu, Wei Xing, Rong-sen Zhao, Yan Tan, Xiao-feng Wu, Luo-quan Ao, Zhan Li, Meng-wei Yao, Mu Yuan, Wei Guo, Shang-ze Li, Jian Yu, Xiang Ao and Xiang Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:270

    Content type: Research

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  9. Renal cell carcinoma (RCC) is a common urological cancer. circular RNAs (circRNAs) is involved in the development of various types of cancers. However, the roles and underlying mechanisms of circRNAs in RCC ar...

    Authors: Jiafu Feng, Yongcan Guo, Yuanmeng Li, Jiawei Zeng, Yaodong Wang, Yuwei Yang, Gang Xie and Qian Feng

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:269

    Content type: Research

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  10. Emerging studies revealed that cancer stem cells (CSCs) possessed peculiar metabolic properties, which however remained largely unknown in hepatocellular carcinoma (HCC). Genetic silencing of liver-abundant mi...

    Authors: Yuanzhuo Gu, Fubo Ji, Niya Liu, Yongzhi Zhao, Xiyang Wei, Shiyuan Hu, Wei Jia, Xin Wei Wang, Anuradha Budhu, Juling Ji, Bin Zhao, Stephanie Roessler, Xin Zheng and Junfang Ji

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:268

    Content type: Research

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  11. Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary way energy is produced to maintain...

    Authors: Lidong Cao, Jiacheng Wu, Xianzhi Qu, Jiyao Sheng, Mengying Cui, Shui Liu, Xu Huang, Yien Xiang, Bingjin Li, Xuewen Zhang and Ranji Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:267

    Content type: Review

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  12. Tumor angiogenesis is regarded as a rational anti-cancer target. The efficacy and indications of anti-angiogenic therapies in clinical practice, however, are relatively limited. Therefore, there still exists a...

    Authors: Lili Quan, Ryuichi Ohgaki, Saori Hara, Suguru Okuda, Ling Wei, Hiroki Okanishi, Shushi Nagamori, Hitoshi Endou and Yoshikatsu Kanai

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:266

    Content type: Research

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  13. In spite of great progress in the surgical and clinical management, until now no significant improvement in overall survival of High-Grade Serous Ovarian Cancer (HGSOC) patients has been achieved. Important as...

    Authors: Marta De Donato, Gabriele Babini, Simona Mozzetti, Marianna Buttarelli, Alessandra Ciucci, Gloria Arduini, Maria Cristina De Rosa, Giovanni Scambia and Daniela Gallo

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:265

    Content type: Research

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  14. It is known that the transcription factor zinc finger protein 703 (ZNF703) plays an important role in physiological functions and the occurrence and development of various tumors. However, the role and mechani...

    Authors: Shuang Wang, Caixia Wang, Yuexin Hu, Xiao Li, Shan Jin, Ouxuan Liu, Rui Gou, Yuan Zhuang, Qian Guo, Xin Nie, Liancheng Zhu, Juanjuan Liu and Bei Lin

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:264

    Content type: Research

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  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zihang Xu, Fei Zhang, Chao Bai, Chao Yao, Hairong Zhong, Chunpu Zou and Xiao Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:263

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:124

  16. Recent genomic analyses revealed that druggable molecule targets were only detectable in approximately 6% of patients with nasopharyngeal carcinoma (NPC). However, a dependency on dysregulated CDK4/6–cyclinD1 ...

    Authors: Zhichao Xue, Vivian Wai Yan Lui, Yongshu Li, Lin Jia, Chanping You, Xin Li, Wenying Piao, Hui Yuan, Pek Lan Khong, Kwok Wai Lo, Lydia Wai Ting Cheung, Victor Ho Fan Lee, Anne Wing Mui Lee, Sai Wah Tsao and Chi Man Tsang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:262

    Content type: Research

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  17. Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem tumor. Most DIPGs harbor a histone H3 mutation, which alters histone post-translational modification (PTM) states and transcription....

    Authors: Shejuan An, Jeannie M. Camarillo, Tina Yi-Ting Huang, Daphne Li, Juliette A. Morris, Madeline A. Zoltek, Jin Qi, Mandana Behbahani, Madhuri Kambhampati, Neil L. Kelleher, Javad Nazarian, Paul M. Thomas and Amanda M. Saratsis

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:261

    Content type: Research

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  18. The E6 oncoproteins of human papillomavirus (HPV) 16/18 are the critical drivers of cervical cancer (CC) progression. Extracellular vesicles (EVs) are emerging as critical mediators of cancer-tumor microenviro...

    Authors: Jun-Jun Qiu, Shu-Gen Sun, Xiao-Yan Tang, Ying-Ying Lin and Ke-Qin Hua

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:260

    Content type: Research

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  19. Emerging evidence suggests that circular RNAs play critical roles in disease development especially in cancers. Previous genome-wide RNA-seq studies found that a circular RNA derived from SOD2 gene was highly ...

    Authors: Zhongwei Zhao, Jingjing Song, Bufu Tang, Shiji Fang, Dengke Zhang, Liyun Zheng, Fazong Wu, Yang Gao, Chunmiao Chen, Xianghua Hu, Qiaoyou Weng, Yang Yang, Jianfei Tu and Jiansong Ji

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:259

    Content type: Research

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  20. Dendritic cells (DCs) secrete vast quantities of exosomes termed as dexosomes. Dexosomes are symmetric nanoscale heat-stable vesicles that consist of a lipid bilayer displaying a characteristic series of lipid...

    Authors: Sepideh Nikfarjam, Jafar Rezaie, Fatah Kashanchi and Reza Jafari

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:258

    Content type: Review

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  21. Gliomas, especially glioblastomas, represent one of the most aggressive and difficult-to-treat human brain tumors. In the last few decades, clinical immunotherapy has been developed and has provided exceptiona...

    Authors: Yuanliang Yan, Shuangshuang Zeng, Zhicheng Gong and Zhijie Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:257

    Content type: Review

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  22. Accumulating evidence suggests that radiation treatment causes an adaptive response of lung adenocarcinoma (LUAD), which in turn attenuates the lethal effect of the irradiation. Previous microarray assays mani...

    Authors: Chun-cheng Hao, Cui-yang Xu, Xin-yu Zhao, Jia-ning Luo, Gang Wang, Li-hong Zhao, Xiaofeng Ge and Xiao-feng Ge

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:256

    Content type: Research

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  23. Dysregulation of cell cycle progression is a common feature of human cancer cells; however, its mechanism remains unclear. This study aims to clarify the role and the underlying mechanisms of Roquin1 in cell c...

    Authors: Wenbao Lu, Meicen Zhou, Bing Wang, Xueting Liu and Bingwei Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:255

    Content type: Research

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  24. Osteosarcoma is generally reported among younger individuals and has a very poor prognosis, particularly for the development of metastasis. However, more effective metastatic biomarkers and therapeutic methods...

    Authors: Ju-Fang Liu, Po-Chun Chen, Tsung-Ming Chang and Chun-Han Hou

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:254

    Content type: Research

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  25. Sphingosine-1-phosphate receptor 2 (S1PR2) mediates pleiotropic functions encompassing cell proliferation, survival, and migration, which become collectively de-regulated in cancer. Information on whether S1PR2 p...

    Authors: Luciana Petti, Giulia Rizzo, Federica Rubbino, Sudharshan Elangovan, Piergiuseppe Colombo, Silvia Restelli, Andrea Piontini, Vincenzo Arena, Michele Carvello, Barbara Romano, Tommaso Cavalleri, Achille Anselmo, Federica Ungaro, Silvia D’Alessio, Antonino Spinelli, Sanja Stifter…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:253

    Content type: Research

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  26. Circular RNA (circRNA) is emerging as an important player in human diseases, especially cancer. In our previous study, we identified a series of deregulated circRNAs in hepatocellular carcinoma (HCC) by perfor...

    Authors: Suofeng Sun, Jing Gao, Shen Zhou, Yuan Li, Yu Wang, Li Jin, Jian Li, Bowei Liu, Bingyong Zhang, Shuangyin Han, Hui Ding and Xiuling Li

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:252

    Content type: Research

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  27. Wingless and Int-related protein (Wnt) ligands are aberrantly expressed in patients with colorectal cancer (CRC). However, the aberrant level of Wnt ligands in serum have not been explored. Here, we aimed to i...

    Authors: Dongmei Yang, Qing Li, Renduo Shang, Liwen Yao, Lianlian Wu, Mengjiao Zhang, Lihui Zhang, Ming Xu, Zihua Lu, Jie Zhou, Li Huang, Xiaodong Huang, Du Cheng, Yanning Yang and Honggang Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:251

    Content type: Research

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  28. Glycolysis plays an essential role in the growth and metastasis of solid cancer and has received increasing attention in recent years. However, the complex regulatory mechanisms of tumour glycolysis remain elu...

    Authors: Zhenqiang Sun, Qiuge Zhang, Weitang Yuan, Xiaoli Li, Chen Chen, Yaxin Guo, Bo Shao, Qin Dang, Quanbo Zhou, Qisan Wang, Guixian Wang, Jinbo Liu and Quancheng Kan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:250

    Content type: Research

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  29. Accumulating evidence showed that regulating tumor microenvironment plays a vital role in improving antitumor efficiency. Programmed Death Ligand 1 (PD-L1) is expressed in many cancer cell types, while its bin...

    Authors: Ze-Bo Jiang, Ju-Min Huang, Ya-Jia Xie, Yi- Zhong Zhang, Chan Chang, Huan-Ling Lai, Wenjun Wang, Xiao-Jun Yao, Xing-Xing Fan, Qi-Biao Wu, Chun Xie, Mei-Fang Wang and Elaine Lai-Han Leung

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:249

    Content type: Research

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  30. The mechanism of histone deacetylase 3 (HDAC3) in colorectal cancer (CRC) has already been discussed. However, the feedback loop of HDAC3/microRNA (miR)-296-3p and transforming growth factor β-induced factor 1...

    Authors: Jinxiao Li, Man Hu, Na Liu, Huarong Li, Zhaomin Yu, Qian Yan, Minfeng Zhou, Yayuan Wang, Yanjuan Song, Guangtao Pan, Fengxia Liang and Rui Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:248

    Content type: Research

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  31. SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might be involved in resistance to anti-cancer th...

    Authors: Zhongkai Zhang, Sang Hoon Ha, Young Jae Moon, Usama Khamis Hussein, Yiping Song, Kyoung Min Kim, See-Hyoung Park, Ho Sung Park, Byung-Hyun Park, Ae-Ri Ahn, Sang-A Lee, Su Jin Ahn, Jung Ryul Kim and Kyu Yun Jang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:247

    Content type: Research

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  32. Cisplatin (CDDP) is the first-line chemotherapy for gastric cancer (GC). The poor prognosis of GC patients is partially due to the development of CDDP resistance. Circular RNAs (circRNAs) are a subclass of non...

    Authors: Guangli Sun, Zheng Li, Zhongyuan He, Weizhi Wang, Sen Wang, Xing Zhang, Jiacheng Cao, Penghui Xu, Haixiao Wang, Xiaoxu Huang, Yiwen Xia, Jialun Lv, Zhe Xuan, Tianlu Jiang, Lang Fang, Jing Yang…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:246

    Content type: Research

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  33. Papillary thyroid cancer (PTC) is the most frequent endocrine tumor. Radioiodine (RAI) treatment is highly effective in these tumors, but up to 60% of metastatic cases become RAI-refractory. Scanty data are av...

    Authors: Carla Colombo, Emanuela Minna, Chiara Gargiuli, Marina Muzza, Matteo Dugo, Loris De Cecco, Gabriele Pogliaghi, Delfina Tosi, Gaetano Bulfamante, Angela Greco, Laura Fugazzola and Maria Grazia Borrello

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:245

    Content type: Research

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  34. Smac mimetics are a type of drug that can induce apoptosis by antagonizing IAP family members in cancer treatment. However, a recent study showed that Smac mimetics can trigger cell invasion and migration in c...

    Authors: Boxiang Zhang, Chengcheng Yang, Rui Wang, Jie Wu, Yunfeng Zhang, Dapeng Liu, Xin Sun, Xiang Li, Hong Ren and Sida Qin

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:244

    Content type: Research

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  35. Radiotherapy is regarded as a milestone for the cure of cervical cancer. However, clinical outcome heavily be hindered by radioresistance. So, exploring the underlying mechanism of radioresistance, and find po...

    Authors: Zongjuan Li, Yang Zhang, Silei Sui, Yijun Hua, Anshi Zhao, Xiaoyuan Tian, Ruonan Wang, Wei Guo, Wendan Yu, Kun Zou, Wuguo Deng, Liru He and Lijuan Zou

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:243

    Content type: Research

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  36. Therapy/prognosis of Non-Small Cell Lung Cancer (NSCLC) patients are strongly related to gene alteration/s or protein expression. However, more than 50% of NSCLC patients are negative to key drugable biomarkers.

    Authors: Michela Terlizzi, Chiara Colarusso, Ilaria De Rosa, Pasquale Somma, Carlo Curcio, Rita P. Aquino, Luigi Panico, Rosario Salvi, Federica Zito Marino, Gerardo Botti, Aldo Pinto and Rosalinda Sorrentino

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:242

    Content type: Research

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  37. Triple negative breast cancer (TNBC) is a heterogeneous disease with aggressive behavior and an unfavorable prognosis rate. Due to the lack of surface receptors, TNBC must be intensely investigated in order to...

    Authors: Cristina Alexandra Ciocan-Cartita, Ancuta Jurj, Oana Zanoaga, Roxana Cojocneanu, Laura-Ancuta Pop, Alin Moldovan, Cristian Moldovan, Alina Andreea Zimta, Lajos Raduly, Cecilia Pop-Bica, Mihail Buse, Liviuta Budisan, Piroska Virag, Alexandru Irimie, Sandra Martha Gomes Dias, Ioana Berindan-Neagoe…

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:241

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:287

  38. Colorectal cancer (CRC) is one of the frequently occurred malignancies in the world. To date, several onco-microRNAs (miRNAs or miRs), including miR-96, have been identified in the pathogenesis of CRC. In the ...

    Authors: Caifeng Yue, Jierong Chen, Ziyue Li, Laisheng Li, Jugao Chen and Yunmiao Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:240

    Content type: Research

    Published on:

  39. Glioblastoma (GBM) is a lethal type of primary brain tumor with a median survival less than 15 months. Despite the recent improvements of comprehensive strategies, the outcomes for GBM patients remain dismal. ...

    Authors: Wahafu Alafate, Dongze Xu, Wei Wu, Jianyang Xiang, Xudong Ma, Wanfu Xie, Xiaobin Bai, Maode Wang and Jia Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:239

    Content type: Research

    Published on:

  40. CD8+ tumor-infiltrating T lymphocytes (T-TILs) in the tumor microenvironment (TME) play an important role in tumor development, and miRNAs regulate tumor cell interactions with the microenvironment. T-TIL-based t...

    Authors: Yangyang Xu, Zhenchuan Liu, Lixin Lv, Ping Li, Bing Xiu, Wenbin Qian and Aibin Liang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:238

    Content type: Research

    Published on:

  41. In follicular lymphoma (FL), histologic transformation to high-grade FL and diffuse large B-cell lymphoma (DLBCL) is a critical adverse step in disease progression. Activation of the oncogene c-MYC and tumor m...

    Authors: Xiaoli Lou, Jianhong Fu, Xin Zhao, Xuemei Zhuansun, Chao Rong, Maomin Sun, Hui Niu, Lei Wu, Yongsheng Zhang, Lu An, Lingchuan Guo, Shan Wan and Shouli Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:237

    Content type: Research

    Published on:

  42. Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different types of tumors, leading to improvement in survival, even in patients with advanced cancers. Despite the good clinical...

    Authors: Simone Camelliti, Valentino Le Noci, Francesca Bianchi, Claudia Moscheni, Francesca Arnaboldi, Nicoletta Gagliano, Andrea Balsari, Marina Chiara Garassino, Elda Tagliabue, Lucia Sfondrini and Michele Sommariva

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:236

    Content type: Review

    Published on:

  43. Long non-coding RNAs (lncRNAs) are crucial in the invasion, angiogenesis, progression, and metastasis of hepatocellular carcinoma (HCC). The lncRNA MYLK-AS1 promotes the growth and invasion of HCC through the ...

    Authors: Fei Teng, Ju-Xiang Zhang, Qi-Meng Chang, Xu-Bo Wu, Wei-Guo Tang, Jian-Fa Wang, Jin-Feng Feng, Zi-Ping Zhang and Zhi-Qiu Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:235

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:277

  44. Cancer-associated fibroblasts (CAFs) and vasculogenic mimicry (VM) play important roles in the occurrence and development of tumors. However, the relationship between CAFs and VM formation, especially in gallb...

    Authors: Mu-Su Pan, Hui Wang, Kamar Hasan Ansari, Xin-Ping Li, Wei Sun and Yue-Zu Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:234

    Content type: Research

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  45. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13046-020-01746-0.

    Authors: Huan Yan, Hong Li, Pengyun Li, Xia Li, Jianjian Lin, Linlin Zhu, Maria A. Silva, Xiaofang Wang, Ping Wang and Zhan Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:233

    Content type: Retraction Note

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:237

  46. Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and is closely associated with poor prognosis. However, the role of TM4SF1 and its potential mechanism in colorectal ...

    Authors: Qiang Tang, Jinhuang Chen, Ziyang Di, Wenzheng Yuan, Zili Zhou, Zhengyi Liu, Shengbo Han, Yanwei Liu, Guoguang Ying, Xiaogang Shu and Maojun Di

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:232

    Content type: Research

    Published on:

  47. Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs particip...

    Authors: Yalu Zhang, Qiaofei Liu and Quan Liao

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:231

    Content type: Review

    Published on:

  48. Lycorine hydrochloride (LH), an alkaloid extracted from the bulb of the Lycoris radiata, is considered to have anti-viral, anti-malarial, and anti-tumorous effects. At present, the underlying mechanisms of LH in ...

    Authors: Chongyang Li, Chaowei Deng, Guangzhao Pan, Xue Wang, Kui Zhang, Zhen Dong, Gaichao Zhao, Mengqin Tan, Xiaosong Hu, Shaomin Shi, Juan Du, Haoyan Ji, Xiaowen Wang, Liqun Yang and Hongjuan Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:230

    Content type: Research

    Published on:

  49. Dysregulation of long non-coding RNAs (lncRNAs) is responsible for cancer initiation and development, positioning lncRNAs as not only biomarkers but also promising therapeutic targets for cancer treatment. A g...

    Authors: Dong-Yan Zhang, Qing-Can Sun, Xue-Jing Zou, Yang Song, Wen-Wen Li, Ze-Qin Guo, Shan-Shan Liu, Li Liu and De-Hua Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:229

    Content type: Research

    Published on:

  50. Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases.

    Authors: Claudio Luchini, Gaetano Paolino, Paola Mattiolo, Maria L. Piredda, Alessandro Cavaliere, Marina Gaule, Davide Melisi, Roberto Salvia, Giuseppe Malleo, Jae Il Shin, Sarah Cargnin, Salvatore Terrazzino, Rita T. Lawlor, Michele Milella and Aldo Scarpa

    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:227

    Content type: Review

    Published on:

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