Fig. 7
From: METTL3-mediated m6A mRNA modification of FBXW7 suppresses lung adenocarcinoma
Proposed model for the function and mechanism of m6A-modified FBXW7 in LUAD. Mechanism of m6A-modified FBXW7-inhibited lung adenocarcinoma (LUAD) growth. FBXW7 may function as a tumor suppressor regulated by METTL3, which installs m6A modifications in the CDS of FBWX7 mRNA and inhibits cell proliferation, ultimately promoting apoptosis via FBXW7 to suppress growth in LUAD