Table 1 In vitro killing efficacy of free Genz-644282 and The-0504 against human cell lines of different origin. Values represent the mean ± SEM (n = 3)
| Cancer cell type |
IC50 (nM) Free Genz-644282 |
IC50 (nM) The-0504 |
|---|---|---|
| HepG2 | 36.0 ± 7.1 | 23 ± 8.1 |
| SNU-484 | 109.3 ± 36.9 | 75.7 ± 2.5 |
| MDA-MB-231 | 19.03 ± 2.6 | 20.1 ± 1.7 |
| A204 | 5.8 ± 0.41 | 4.44 ± 0.33 |
| HT1080 | 5.4 ± 0.8 | 4.1 ± 0.5 |
| SJSA-1 | 25.5 ± 3.8 | 251.7 ± 8.5 |
| PaCa44 | 150.4 ± 30.6 | 100.4 ± 19.3 |
| MIA PaCa-2 | 26.1 ± 2.6 | 14.5 ± 1.6 |
| PANC-1 | 11.6 ± 1.3 | 14.2 ± 2.5 |
| HT-29 | 160.3 ± 20.5 | 21.0 ± 2.1 |