Fig. 4

Anti-tumor activity of The-0504 in mice bearing orthotopic HT-29 tumors. a Survival curves of different animal groups. Animals were sacrificed when they showed signs of pain or cachexia. Statistical analysis was performed by log-rank test. Control vs The-0504: **p < 0.005; Genz-644282 vs The-0504: *p < 0.05. b Representative bioluminescence images of HT-29 lung metastases. Images of three mice/group 10 days after the last treatment (i.e., 30 days after therapy start) are shown. Primary tumors are covered by a black paper to avoid possible camera saturation