Table 3 LncRNAs that regulate AS in cancer
From: Noncoding RNAs regulate alternative splicing in Cancer
| LncRNA | Function | Cancer | Reference |
|---|---|---|---|
| Saf | Interaction with Fas pre-mRNA through the cis-NAT form | Leukemia, cervical cancer | [44] |
| EGOT | Interaction with ITPR1 pre-mRNA through the cis-NAT form | Breast cancer | [46] |
| Zeb2 | Interaction with Zeb2 pre-mRNA through the cis-NAT form | Breast cancer | [47] |
| BC200 | Interaction with Bcl-x pre-mRNA through the trans-NAT form | Breast cancer | [50] |
| CCAT2 | Interaction with GLS pre-mRNA through the trans-NAT form | Colorectal cancer | [52] |
| UCA1 | Sponging miR-184-mediated AS | Oral squamous cell carcinoma | [77] |
| CCAT1 | Sponging miR-490-mediated AS | Gastric cancer | [64] |
| MALAT1 | Promoting SRPK1-catalyzed SRSF1 phosphorylation | Colorectal cancer | [80] |
| LINC01133 | Decoying the SF SRSF6 away from the targeted pre-mRNA | Colorectal cancer | [92] |
| PCGEM1 | Decoying the SF HnRNPA1 away from the targeted pre-mRNA | Prostate cancer | [87] |
| TPM1-AS | Decoying the SF RBM4 away from the targeted pre-mRNA | Esophageal cancer | [88] |
| FAS-AS1 | Decoying the SF RBM5 away from the targeted pre-mRNA | B-cell lymphomas | [93] |
| PNCTR, PANDAR, LUCAT1 | Decoying the SF PTBP1 away from the targeted pre-mRNA | Cervical cancer osteosarcoma, colorectal cancer | [89], [94], [95] |
| MALAT1 | Decoying the SF SFPQ away from the targeted pre-mRNA | Colorectal cancer | [96] |
| Gomafu | Decoying the SF SF1 and Celf3 away from the targeted pre-mRNA | Neuroblastoma | [97] |
| Spry1 | Decoying the SF U2AF65 away from the targeted pre-mRNA | Breast cancer | [98] |
| LASTR | Decoying the SF SART3 away from the targeted pre-mRNA | Breast cancer | [99] |
| asFGFR2 | Fine-tuning the chromatin structure to decrease the recruitment of the SF PTB | Breast cancer | [101] |
| HOXB-AS3 | Encoding peptides to inhibit hnRNPA1-mediated AS | Colon cancer | [103] |